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Tuesday, July 8, 2008
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Tardive dyskinesiaDefinitionTardive dyskinesia is a disorder that causes involuntary movements (especially of the lower face). CausesTardive dyskinesia is serious side effect of long-term use of drugs called neuroleptics. The most commonly used neuroleptics are older anti-psychotic drugs, including haloperidol, trifluoperazine, or fluphenazine. SymptomsThe abnormal movements include tongue thrusting, repetitive chewing, jaw swinging, or facial grimacing. Outlook (Prognosis)If diagnosed early, the condition may be reversed by stopping the drug that caused the symptoms. In some cases, even if the antipsychotic drugs are stopped, the involuntary movements may become significantly worse or permanent. Nasrallah HA. Focus on lower risk of tardive dyskinesia with atypical antipsychotics. Ann Clin Psychiatry. 2006 Jan-Mar;18(1):57-62. Chen JJ, Lee KC. Nonparkinsonism movement disorders in the elderly. Consult Pharm. 2006 Jan;21(1):58-71. Margolese HC, Chouinard G, Kolivakis TT, Beauclair L, Miller R. Tardive dyskinesia in the era of typical and atypical antipsychotics. Part 1: pathophysiology and mechanisms of induction. Can J Psychiatry. 2005 Aug;50(9):541-7. Review.
Review Date: 4/28/2006 Reviewed By: Daniel Kantor, M.D., Director of the Comprehensive MS Center, Neuroscience Institute, University of Florida Health Science Center, Jacksonville, FL. Review provided by VeriMed Healthcare Network. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Copyright A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited. |