She earned her MD from the University of Chicago and completed training in internal medicine and medical oncology at the University of Minnesota, where she became a full professor in seven years.

In 1989 she became professor of medicine and chief of the Division of Oncology at the State University of New York at Buffalo, as well as chair of the Division of Medicine at Roswell Park Cancer Institute. She came to Ohio State in 1997, and in 2000 she was elected to the Institute of Medicine of the National Academy of Sciences. At the OSUCCC, she serves as cancer scholar and senior adviser. She is also a member of the Molecular Biology and Cancer Genetics Program, a professor of internal medicine and holder of the William Greenville Pace III Endowed Chair in Cancer Research.

Dr. Bloomfield is renowned for her more than three decades of research in adult leukemia and lymphoma - research that has been described in more than 600 publications and which has helped change standards of treatment.