CV: Doreen M Agnese MD

Doreen M Agnese, MD
Assistant Professor
Division of Surgical Oncology
Department of Surgery
College of Medicine
The Ohio State University

Answers questions in the following forums:

Practice Address:

614-293-4040

Education:

UMDNJ-Robert Wood Johnson Medical School
Piscataway, New Jersey
M.D. May 1993
Drew University
Madison, New Jersey
B.A. in Biology
May 1989

Post Graduate Training:

The Ohio State University
Columbus, Ohio
Clinical Cancer Genetics
4/1/03-3/31/04
The Ohio State University
Columbus, Ohio
Surgical Oncology
7/1/01-3/31/03
4/1/04-6/30/04
UMDNJ-Robert Wood Johnson Medical School
Piscataway/New Brunswick, New Jersey
Chief Resident in General Surgery
7/1/98-6/30/99
UMDNJ-Robert Wood Johnson Medical School
Piscataway/New Brunswick, New Jersey
PGY-III & PGY-IV Residency in General Surgery
7/1/96-6/30/98
UMDNJ-Robert Wood Johnson Medical School
Piscataway/New Brunswick, New Jersey
PGY-I & PGY-II Residency in General Surgery
7/1/93-6/30/95

Licensure or Certification:

Diplomat, American Board of Surgery, Certificate, 9/11/00.

Associations:

American College of Surgeons
Society of Surgical Oncology
Association of Women Surgeons
American Society of Breast Surgeons
American Association for Cancer Research
American Society of Human Genetics

Affiliations:

Assistant Professor
Surgical Oncology and Clinical Cancer Genetics, James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, OH, 7/1/04-present.
Clinical Instructor
UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey, 8/7/00-6/8/01.

Partial List of Publications:

Agnese DM, Maupin R, Tillman B, Pozderac RD, Magro C, Walker MJ. Head and neck melanoma in the sentinel node era. Submitted to Archives of Otolaryngology—Head & Neck Surgery, August 1, 2006.
Agnese DM, Hampel H, Farrar WB. Utilization of genetic counseling by surgical oncologists: education a must. Clinical Genetics, in press.
Povoski SP, Olsen JO, Young DC, Clarke J, Burak WE, Walker MJ, Carson WE, Yee LD, Agnese DM, Pozderac RV, Hall NC, Farrar WB. Prospective randomized clinical trial comparing intradermal, intraparenchymal, and subareolar injection routes for sentinel lymph node mapping and biopsy in breast cancer. Ann Surg Oncol 2006, in press.
Agnese DM. Battle of the BRCA1/BRCA2 (offspring) sex ratios: truth or consequences? J Med Genet, 2006, 43: 201-202.
Xiao J, Horst S, Hinkle G, Cao X, Kocak E, Fang J, Young D, Khazaeli M, Agnese D, Sun D, Martin E. Pharmacokinetics and Clinical Evaluation of (125)I-Radiolabeled Humanized CC49 Monoclonal Antibody (HuCC49DeltaC(H)2) in Recurrent and Metastatic Colorectal Cancer Patients. Cancer Biother Radopharm, 2005; 20(1): 16-26.
Agnese DM, Burak WE. Ablative Approaches to the Minimally Invasive Treatment of Breast Cancer. The Cancer Journal, 2005, 11(1): 77-82.
Agnese DM. Advances in Breast Imaging. Surgical Technology International XIV 2005; 14: 51-56.
Chandler JJ, Agnese DM. “Head and Neck Lesions,” Learning Surgery: The Surgery Clerkship Manual, New York: Springer-Verlag, 2005, 177-199.
Agnese DM. The genetics of breast cancer: what the general surgeon should know. General Surgery News. August 2004.
Agnese DM, Abdessalam SF, Burak WE, Arnold MW, Soble D, Hinckle GH, Young D, Khazelli MB, Martin EW. Pilot study using humanized CC49 monoclonal antibody (HuCC49?CH2 Mab) to localize recurrent colorectal carcinoma. Annals of Surgical Oncology, 2004; 11(2): 197-202.
Agnese DM, Yusuf F, Wilson JL, Shapiro CL, Lehman A, Burak WE. Trends in breast cancer presentation and care according to age in a single institution. The American Journal of Surgery 2004; 188(4): 437-439.
Burak WE, Agnese DM, Povoski SP. Advances in the Surgical Management of Early Stage Invasive Breast Cancer. Current Problems in Surgery 2004; 44(11): 882-935.
Agnese DM, Williams J, Burak WE. Isolated supraclavicular lymph node recurrence after breast conservation surgery and negative axillary sentinel node biopsy. The Breast Journal, November 2003; 9(6): 501-502.
Burak WE, Agnese DM, Povoski SP, Yanssens TL, Bloom KJ, Wakely PE, Spigos DG. Radiofrequency ablation of invasive breast cancer followed by delayed surgical excision. Cancer, October 1, 2003; 98(7): 1369-1376.
Agnese DM, Abdessalam SF, Burak WE, Magro CM, Pozderac RV, Walker MJ. Cost-effectiveness of sentinel lymph node biopsy in thin melanomas. Surgery, October 2003; 134(4): 542-547.
Calvano JE, Um JY, Agnese DM, Hahm SJ, Kumar A, Coyle SM, Calvano SE, Lowry SF. Influence of the TNF-? and TNF-? polymorphisms upon infectious risk and outcome in surgical intensive care patients. Surgical Infections, 2003; 4(2): 163-169.
Calvano JE, Agnese DM, Um JY, Goshima M, Singhal R, Coyle SM, Reddell MT, Kumar A, Calvano SE, Lowry SF. Modulation of the LPS receptor complex (CD14, TLR4, MD-2) and TLR2 in SIRS positive patients with and without infection: relationship to tolerance. Shock, 2003; 20(5): 415-419.
Agnese DM, Calvano JE, Hahm SJ, Coyle SM, Corbett SA, Calvano SE, Lowry SF. Human Toll-like receptor 4 (hTLR4) mutations, but not CD14 polymorphisms, are associated with an increased incidence of gram-negative infections. Journal of Infectious Diseases, November 15,2002; 186(10): 1522-5.
Agnese DM, Calvano JE, Hahm SJ, Calvano SE, Lowry SF. Insulin-like Growth Factor Binding Protein-3 is Upregulated in LPS-treated THP-1 Cells. Surgical Infections, 2002 Summer; 3(2): 119-126.
Agnese DM, Lowry SF. Back to the Future: Is Lipid A an Appropriate Target for the Therapy of Sepsis? Critical Care Medicine, August 2000; 28(8): 3084-3086.
Deshmukh DR, Mirochnitchencko O, Ghole VS, Agnese D, Shah PC, Reddell M, Brolin RE, Inouye M. Intestinal Ischemia and Reperfusion Injury in Transgenic Mice Overexpressing Copper-Zinc Superoxide Dismutase. American Journal of Physiology, October 1997; 273 (4 Pt 1): C1130-5.
Deshmukh DR, Mirochnitchencko O, Agnese D, Ghole VS, Brolin RE, et al. Protection Against Intestinal Ischemia/Reperfusion Injury in Transgenic Mice Overexpressing Superoxide Dismutase. Ped Res, April 1996; 39: 118A.
Deshmukh DR, Mirochnitchencko O, Agnese D, Brolin RE, Inouye M. Transgenic Mice Overexpressing Superoxide Dismutase (SOD) Gene are Resistant to Reperfusion Injury, FASEB Journal, March 1996; 10: A822.
Agnese DM, Deshmukh DR, Mirorchnitchencko O, Kantha R, Inouye M, Brolin RE. Transgenic Mice Overexpressing Human CuZnSOD are Protected from Lung Injury Induced by Intestinal Ischemia and Reperfusion. Surgical Forum, 1996; 47:185-187.

Research:

Research Fellowship
UMDNJ-Robert Wood Johnson Medical School
New Brunswick, New Jersey
Research Topic: Sepsis. 7/1/99-6/8/01.
Research Fellowship
UMDNJ-Robert Wood Johnson Medical School
New Brunswick, New Jersey
Research Topic: Intestinal Ischemia and Reperfusion. 7/1/95-6/30/96.

Grants:

John Wayne Cancer Institute, NCI Funds
A phase III multicenter randomized trial of sentinel lymphadenectomy and complete lymph node dissection versus sentinel lymphadenectomy alone in cutaneous melanoma with molecular or histopathological evidence of metastases in the sentinel node.
Amount: $42,800
5/1/06-5/31/06
Role: Co-investigator (5% salary recovery)
Perceived Recurrence Risk in Breast Cancer Patients
American Cancer Society, Ohio Division
Amount: $30,000
1/1/06-12/31/06
PI: Kimberly Kelly, PhD
Role: Co-Investigator
This study proposes to examine perceived breast cancer recurrence risk in cancer patients and survivors.

Partial List of Presentations:

“Prophylactic mastectomy and reconstruction options: old standards and new innovations.” Invited for Education Breakout Session at National Society of Genetic Counselors Annual Meeting, Nashville, TN, November 12, 2006.
“Are you at high risk for breast cancer? Options and Treatment. Presented at the annual Breast Cancer Awareness Program, “Sharing the Journey of Hope with a Breast Cancer Survivor” program, Zanesville, OH, October 26, 2006.
Head and neck melanoma in the sentinel node era. Presented at the American Head & Neck Society Annual Meeting, Chicago, IL, August 19, 2006.
A single center validation study of a nomogram for the prediction of positive sentinel lymph nodes in melanoma. Presented at the 59th Annual Society of Surgical Oncology Meeting, San Diego, CA, March 23-26, 2006.
Visiting Professorship & General Surgery Grand Rounds (topic: Surgical Implications of Cancer Genetics). St. Luke’s Hospital, Bethlehem, PA. March 14-15, 2006.
Utilization of genetic counseling services by surgical oncologists: education a must. 55th Annual Meeting, The American Society of Human Genetics. Salt Lake City, UT. Oct 28, 2005.
Visiting Professorship & General Surgery Grand Rounds (topic: Breast Cancer Genetics). Easton Hospital, Easton PA. February 3-4, 2005.
Breast Cancer: a genetic and Surgical Perspective. Internal Medicine Grand Rounds, Columbus, OH. The Ohio State University. October 7, 2004.
The Genetics of Breast Cancer. Surgical Grand Rounds. The Ohio State University, Columbus, OH. September 2, 2004.
The Genetics of Breast Cancer. Presented at the Central Ohio Case Management Network Meeting, Worthington, OH, May 12, 2004.
Surgical Interventions for Individuals at Hereditary Cancer Risk. Presented at the Cancer Genetics Short Course, Columbus, OH, April 22, 2004.
Trends in Breast Cancer Presentation and Care According to Age in a Single Institution. Presented at the 5th Annual American Society of Breast Surgeons Meeting, Las Vegas, NV, March 31-April 4, 2004.
Genetics and Breast Cancer: What the Surgical Oncologist Should Know. Presented at the 57th Annual Society of Surgical Oncology Meeting, New York, NY, March 19, 2004.
Clinicopathologic variables predictive of positive nodes in melanoma in the era of sentinel nodes. Presented at the 57th Annual Society of Surgical Oncology Meeting, New York, NY, March 18-21, 2004.
Genetics of Breast Cancer. Presented at the Ohio Cancer Registrars Association Annual Education Meeting, Columbus, OH, September 17, 2003.
Cost-effectiveness of sentinel lymph node biopsy in thin melanomas. Presented at the 60th Annual Meeting of the Central Surgical Association, Toronto, Canada, March 20, 2003.
Pilot study using humanized CC49 monoclonal antibody to localize recurrent colorectal carcinoma. Presented at the 56th Annual Society of Surgical Oncology Meeting, Los Angeles, CA, March 7, 2003.
MRI appearance of breast cancer following radiofrequency ablation. Presented at the 56th Annual Society of Surgical Oncology Meeting, Los Angeles, CA, March 7, 2003.
Genetic Regulation of Monocyte Apoptosis in Endotoxemic Volunteers. Presented at the Surgical Forum, American College of Surgeons Fall Meeting, New Orleans, LA; October 8, 2001.
Human Toll-like receptor 4 (hTLR4) mutations are associated with an increased incidence of gram-negative infections and increased mortality. Presented at the Surgical Forum, American College of Surgeons Fall Meeting, New Orleans, LA; October 8, 2001.
Insulin-Like Growth Factor Binding Protein 3 is Upregulated in LPS-Treated THP-1 Cells. Presented at the Surgical Infection Society, Snowbird, UT; May 3, 2001.
Overexpression of CuZnSOD Protects Transgenic Mice from Lipid Peroxidation in Intestinal Ischemia/Reperfusion. Presented at the Association for Academic Surgery; Chicago, IL; November 15, 1996.
Transgenic Mice Overexpressing Human CuZnSOD are Protected from Lung Injury Induced by Intestinal Ischemia and Reperfusion. Presented at the Surgical Forum, American College of Surgeons Fall Meeting; San Francisco, CA; October 8, 1996.
Stress Among Surgical Residents. Presented at the Association of Program Directors in Surgery; Phoenix, AZ; March 14, 1996.

Awards:

William P. Burks Humanist Award (Robert Wood Johnson Residency Program), 1999.
Academic Achievement Award (Robert Wood Johnson Residency Program), 1996.
Drew University graduate, magna cum laude, 1989.
New Milford High School Valedictorian, 1985.
Drew Scholarship, 1985-1989.
New Jersey Distinguished Scholar Award, 1985-1989.
Phi Beta Kappa National Honor Society
Beta Beta Beta National Biology Honor Society
Sigma Delta Pi National Spanish Honor Society

Answers questions in the following forums:

Practice Address:

Education:

Post Graduate Training:

Licensure or Certification:

Associations:

Affiliations:

Partial List of Publications:

Research:

Grants:

Partial List of Presentations:

Awards:

Web Links: