Practice Address:

Veterans Administration Medical Center
3200 Vine Street
Cincinnati, OH 45220

Education:

• B.A. Queens College, New York City, NY
• M.D. Yale University School of Medicine, New Haven, CT

Post Graduate Training:

• Internship in Internal Medicine, Yale-New Haven Hospital, New Haven, CT
• Residency in Internal Medicine, Yale-New Haven Hospital, New Haven, CT
• Research Associate, Laboratory of Immunology, NIAID, NIH, Bethesda, MD
• Fellow in Rheumatology, University of Texas-Southwestern Medical School, Dallas, TX

Licensure or Certification:

• Maryland State Board of Medical Examiners
• Ohio State Board of Medical Examiners
• National Board of Medical Examiners
• American Board of Internal Medicine
• American Board of Internal Medicine, Rheumatology

Associations:

• American Society for Clinical Investigation
• American Association of Immunologists
• American College of Rheumatology
• American Rheumatology Association

Affiliations:

• University Hospital, Cincinnati, OH
• Veterans Administration Medical Center, Cincinnati, OH

Partial List of Publications:

• Gause, W.C., R. Greenwald, M. Halvorson, P.Lu, W. diZhou, S.J. Chen, S.C. Morris, K. Lee, C. June, F.D. Finkelman, J.F. Urban and R. Abe. 1997. CD28-dependence of T cell differentiation to IL-4 production varies with the particular type 2 immune response. J. Immunol. 158:4082.
• Madden, K.B., F.D. Finkelman, J.F. Urban, Jr., A. Svetic, W.C. Gause and I.M. Katona. The role of cytokines in helminth-induced mucosal mast cell hyperplasia. Submitted for publication.
• Greenwald, R., P. Lu, M. Halvorson, X. Zhou, S. Chen, K.B. Madden, P.J. Perrin, S.C. Morris, R. Peach, F.D. Finkelman, J.F. Urban, Jr. and W.C.Gause. 1997. The role of CD80 and CD86 in the development of an in vivo type 2 immune response. J. Immunol. 158:4088.
• Brunet, L.R., F.D. Finkelman, A.W. Cheever, M.A. Kopf and E.J. Pearce. 1997. IL-4 protects against TNF-a medicated cachexia and death during acute schistosomiasis. J. Immunol. 159:777-85.
• Roes, J., M. Epstein, I. Wolowezuk, F. Finkelman, P. Matzinger and K. Rajewsky. Impaired T cell help in B cell-deficient mice. Submitted for publication.
• Valenzona, H.O., S. Dhanoa, F.D. Finkelman, A. Namen and D.G. Osmond. Exogenous interleukin-7 as a proliferative stimulant of early precursor B cells in mouse bone marrow: efficacy of IL-7 injection, IL-7 infusion and IL-7 - anti-IL-7 antibody complexes. Submitted for publication.
• Comoy, E.E., J. Pestel, C. Duez, G.A. Stewart, C. Vendeville, C. Fournier, F. Finkelman, A. Capron and G. Thyphronitis. 1998. The house dust mite allergen, Der pl, promotes type 2 responses by modulating the balance between IL-4 and IFN-g. J. Immunol., In press.
• Greenwald, R.J., D. Nguyen, F.D. Finkelman, P.S. Linsley, A. Sharpe, J.F. Urban, Jr. and W.C. Gause. Neither CD 28 nor B7-2 is required for germinal center formation during a B7-dependent type 2 in vivo mucosal immune response. Submitted for publication.
• Morris, S.C., R.L. Cofman and F.D. Finkelman. 1998. In vivo IL-4 responses to anti-IgD antibody are MHC class II-dependent, b2-microglobulin-independent, and Stat6-independent. J. Immunol. In press.
• Grieder, F.B., B.K. Davis, X.D. Zhou, S.J. Chen, F.D. Finkelman and W.C. Gause. 1997. Kinetics of cytokine expression and regulation of host protection following infection with molecularly cloned Venezuelan equine encephalitis virus. Virology 233:302-12.

Research:

• Regulation of lymphocyte activation and tolerization
• Regulation of lymphopoiesis
• Cytokine regulation of protective immunity
• Cytokine regulation of allergic inflammation
• Regulation of T lymphocyte cytokine production

Hospital Appointments:

• University Hospital, Cincinnati, OH
• Veterans Administration Medical Center, Cincinnati, OH

Grants:

• NIH. Cytokine enhancement of an anti-nematode vaccine. 1994-1998. Direct funding: $396,942.
• NIH. Role of interleukin-4 in host immunity to nematodes. 1994-1998. Direct funding: $298,330.
• National Arthritis Foundation (Biomedical Science Grant). Effects of membrane Ig crosslinking on the lifespan of mature B cells in vivo. 1995-1998. Direct funding: $208,332.
• Veterans Administration Merit Award. Regulation of asthma by IL-4 and IL-5. 1997-2002. Direct funding approximately $460,000.
• Genetics Institute. Regulation of asthma by IL-12. 1996-1998. Direct funding: $64,000.

Partial List of Presentations:

• Symposium Speaker and Minisymposium Chair, AAI Annual Meeting, San Francisco, CA
• Chicago Immunology Society, Chicago, IL
• Cornell University College of Medicine, New York, NY
• British Society for Parasitology Manchester, UK
• University of Southern Ontario College of Medicine, London, Ontario, Canada
• Case Western Reserve College of Medicine, Cleveland, OH
• Genetics Institute, Cambridge, MA
• Idiotype Meeting, Toulouse, France
• Immunex Corporation, Seattle, WA
• Australasian Immunology Society Annual Meeting, Perth, Australia
• AAAAI Annual Meeting, Washington, DC
• Johns Hopkins College of Medicine, Baltimore, MD
• Aspen Allergy Meeting, Aspen, CO
• Monod Conference on Parasitology, Aussois, France
• British Society of Immunology Meeting, Harrogate, UK