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Senior Health

Neuropathy and Zoloft

03/06/2001

Question:

I have neuropathy in my foot. Along with neurontin my doctor has recommended taking zoloft for the beneficial side effects of the drug. How does this work to reduce the pain?

Answer:

Zoloft (sertraline), a SSRI antidepressant, is an adjuvant in chronic pain relief of neuropathic origin by altering the neurotransmitters in the brain and also helping depression/anxiety associated with chronic pain, sort of breaks the cycle of pain-depression-heightened pain awareness. SSRI are safer agents compared to the tri-cyclic agents (Amitriptyline) used as adjuncts in pain management in the past and now being frequently used.

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Response by:

Elizabeth Joyner Gothelf, BSN, MAG Elizabeth Joyner Gothelf, BSN, MAG
Assistant Director
College of Medicine
University of Cincinnati

Arvind   Modawal, MD, MPH, MRCGP Arvind Modawal, MD, MPH, MRCGP
Professor of Family & Community Medicine, Geriatrics and Palliative Care
College of Medicine
University of Cincinnati