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Lung Transplantation

Special Antibodies

08/25/2009

Question:

If a patient has high antibody levels, is there anything that they can do about this? Is it possible to reduce the level of antibodies?

Answer:

High pre-formed antibody levels are a complicating factor during lung transplantation. These are found in women with multiple births or in a patient that may have received multiple blood transfusions. Generally, careful donor organ matching before transplantation and the consideration of a number of different treatments around the time of transplant is the way most transplant centers treat this potential problem.

High preformed antibodies in heart transplant recipients are occasionally treated with medicines or treatments to reduce the antibody production prior to transplant.

No simple treatments, diet or lifestyle modification would be expected to change the antibody levels.

For more information:

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Response by:

Case Western Reserve University Robert Schilz, DO, PhD
Associate Professor
Division of Pulmonary, Critical Care and Sleep Medicine
University Hospitals
School of Medicine
Case Western Reserve University
Robert  Schilz, DO, PhD