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NetWellness provides the highest quality health information and education services created and evaluated by faculty of our partner universities.
Saturday, November 21, 2009
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NetWellness provides the highest quality health information and education services created and evaluated by faculty of our partner universities.
Saturday, November 21, 2009
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Pharmacy and Medications |
Lipitor11/02/2009 |
Can you please give me a brief explanation why statins are usually given at night?
Thank you for contacting NetWellness. Statins are commonly administered in the evening or at bedtime because most have short half-lives and because peak cholesterol biosynthesis in our body occurs between midnight and 3 a.m.
Lovastatin, fluvastatin, pravastatin, and simvastatin have half-lives of less than 6 hours and therefore are always taken in the evening. However, Lipitor (atorvastatin) has a long half-life of 14 to 30 hours. A few studies found that changes in cholesterol levels were similar after morning and evening administration of Lipitor, suggesting that Lipitor may be administered in the morning or evening.
Submitted by: Sadika Ali. PharmD Candidate 2010. The Ohio State University-College of Pharmacy
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Carmen M. Hadley, RPh, CSPI Clinical Instructor Central Ohio Poison Center Nationwide Children’s Hospital College of Pharmacy The Ohio State University |
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